Inflammation in the intervertebral disc herniation ...

 · Inflammation is an adaptive response triggered by harmful stimuli such as an infection or tissue lesion. Tissue stress also induces a similar response, described as "parainflammation", creating an intermediate condition between the homoeostatic baseline state and the classic inflammatory response. 31 Such inflammation, which is unrelated to defence of the host, in the intervertebral disc ...

Inflammation in the intervertebral disc herniation ...

 · The depolarisation of these ion channels probably plays a role in radicular pain, a relationship which indies a direct link between PIC, neurotrophins and nociception. 34 In the laboratory, the appliion of NP to the nerve root causes ectopic discharges 114 and to the dorsal ganglion induces an increase in excitability and mechanical hypersensitivity 115 .

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A Review: Marine Biologging of Animal Behaviour and Ocean ...

 · Recent technologies have allowed researchers to observe animal behaviour and monitor their surrounding environments by deploying electronic sensors onto the animals. Socalled 'biologging' (also known as animal telemetry, biotelemetry, or animalborne sensors) has been widely used to study marine animals that are difficult for humans to observe. In this study, we (1) review the types of ...

The 3D organisation of mitochondria in primate ...

 · Figure 1. 3D rendering of complete segmentation of every mitochondrion in a small, healthylooking cone. ( A) Three panels represent 90 degree rotations of the ellipsoid of a cone cell showing all ...

26th Annual Computational Neuroscience Meeting (CNS*2017 ...

Robert A. McDougal 1, William W. Lytton 2,3 1 Neuroscience, Yale University, New Haven, CT 06520, USA; 2 Physiology Pharmacology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA; 3 Kings County Hospital, Brooklyn, NY 11203, USA Correspondence: Robert A. McDougal () BMC Neuroscience 2017, 18 (Suppl 1):P157. A neuron's electrical .

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Conductive polymers have been used for various biomedical appliions including biosensors, tissue engineering and regenerative medicine. However, the poor processability and brittleness of these polymers hinder the fabriion of threedimensional structures .

An Overview of FGF23 as a Novel Candidate Biomarker of ...

 · Ltype calcium channels at the sarcolemma open due to the depolarisation of the AP, allowing the first Ca 2+ influx into the cytoplasm (Fabiato and Fabiato, 1975). This Ca 2+ influx activates ryanodine receptors (RyRs), triggering a greater amount of Ca 2+ release from the sarcoplasmic reticulum (SR) to the cytoplasm .

Conditional and Reversible Activation of Class A and B G ...

Understanding the activation and internalization of G proteincoupled receptors (GPCRs) using conditional approaches is paramount to developing new therapeutic strategies. Here, we describe the design, synthesis, and testing of ExONatide, a benzylguaninelinked peptide agonist of the glucagonlike peptide1 receptor (GLP1R), a class B GPCR required for maintenance of glucose levels in humans.

Dependence of the Excitability of Pituitary Cells on ...

 · Cyclic 3′,5′‐adenosine monophosphate and cyclic 3′,5′‐guanosine monophosphate are intracellular (second) messengers that are produced from the nucleotide triphosphates by a family of enzymes consisting of adenylyl and guanylyl cyclases. These enzymes are involved in a broad array of signal transduction pathways mediated by the cyclic nucleotide monophosphates and their kinases ...

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A preferential pole for exocytosis in cultured chromaffin ...

 · Depolarisation was performed using a 70 mM K + KrebsHEPES solution (isosmotic reduction of Na +). Over each field of cells we performed a Zseries (Z step: 2 μm) to determine its height. An optical section was selected to scan and measure the fluorescence. Time 0 was considered the time at which we applied 5 μM FM143 in KrebsHEPES solution.

ERPM junctions: Structure, function and dynamics ...

ERplasma membrane (PM) junctions mediate crucial activities ranging from Ca (2+) signaling to lipid metabolism. Spatial organization of ERPM junctions may modulate the extent and loion of ...

SFEndocrino

[2] Hodson DJ, Schaeffer M, Romanò N, Fontanaud P, Lafont C, Birkenstock J, Molino F, Christian H, Lockey J, Carmignac D, FernandezFuente M, Le Tissier P, Mollard P 2012. Existence of longlasting experiencedependent plasticity in endocrine cell networks. Nat Commun. 2012 Jan 3;3:605. doi: /ncomms1612. PMID:

(PDF) Traitement ostéopathique de patients souffrant de ...

Traitement ostéopathique de patients souffrant de lombalgies chroniques communes

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OSMOSENSING, OSMOSIGNALLING AND INFLAMMATION: HOW ...

may involve depolarisation and reorganisation of the actin cytoskeleton and initiation of calcium transits from the intracellular stores (Pritchard et al., 2002). Interestingly, the response to the hyperosmoticallyinduced volume changes may be zonedependent (AF vs. NP) due to the differences in the mechanical composition of these cells.

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Alterations in mitochondrial morphology as a key driver of ...

 · Molino D, PilaCastellanos I, Marjault H, Dias Amoedo N, Kopp K, Rochin L, Karmi O, Sohn Y, Lines L, Hamaï A et al (2020) Chemical targeting of NEET proteins reveals their function in mitochondrial morphodynamics. EMBO Rep 21: e49019 Wiley Online Library CAS PubMed Web of Science® Google Scholar; 74.

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The role of beta cell heterogeneity in islet function and ...

 · It is becoming increasingly apparent that not all insulinsecreting beta cells are equal. Subtle differences exist at the transcriptomic and protein expression levels, with repercussions for beta cell survival/proliferation, calcium signalling and insulin release. Notably, beta cell heterogeneity displays plasticity during development, metabolic stress and type 2 diabetes mellitus (T2DM). Thus ...

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The purpose is to see semiotics in its different dimensions as well as in its appliions in different disciplinary areas such as media, anthropology, biosemiotics, architecture, dance, film, literature, discourse, gestures and above all its

(PDF) Antimicrobial Activity of Carvacrol: Current ...

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Dependence of the excitability of pituitary cells on ...

 · In cells that are not firing AP, depolarisation also facilitates Ca 2+ influx through Ca v channels. The regulatory function of these channels is based on the Ca 2+ influx during the transient depolarisation, which acts as an intracellular messenger, controlling a variety of cellular functions.